Inhibition of amylase secretion from differentiated AR4-2J pancreatic acinar cells by an actin cytoskeleton controlled protein tyrosine phosphatase activity
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چکیده
منابع مشابه
Role of the actin cytoskeleton in acinar cell protein secretion
All eukaryotic cells, including the pancreatic acinar cell, tightly control organization of their cytoplasm which in large part relies on the cytoskeleton. The cytoskeleton is comprised of three filament types: microtubules (tubulin), intermediate filaments (keratins), and microfilaments (actin). In addition to characteristics common to all cells, the pancreatic acinar cell is a polarized epith...
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Polyamines are polycationic molecules essential for cell growth and differentiation. Recent work has focused on cell polyamine-transport systems as a way to regulate intracellular polyamine levels. In this study, we demonstrate the presence of two different active transporters for putrescine and spermidine in a rat tumoral cell line (AR4-2J). The first has a Km of 3.1 microM and a Vmax of 3.7 p...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1999
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(99)00592-x